| Autor: |
Mohammad Yasin, Karami, Nasrin, Mansournia, Neda, Bagherian, Alireza, Makarem, Nader, MoeinVaziri, Sahar, Borna, Amir Hossein, Pourdavood, Iman, Shamohammadi |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Veterinary Medicine : Research and Reports |
| ISSN: |
2230-2034 |
| Popis: |
Objective To evaluate the effects of azelnidipine-carboxyl methyl cellulose (AZL-CMC) gel and carboxyl methyl cellulose 2% gel (CMC) on the healing of full-thickness skin wounds of diabetic rats. Methods Fifteen Sprague Dawley male rats were studied. The rats were divided into three groups: AZL-CMC gel-treated, CMC 2% gel-treated, and control group. Wounds were assessed by wound area measurement every 3 days and histopathology samples were collected at 4, 7 and 12 days post wounding to evaluate the healing process using stereological study. Mann–Whitney U-test repeated measurement and non-parametric one-way analysis of variance (ANOVA) were used to analyze the data using SPSS, version 18. Results Numerical density of the fibroblasts of the AZL-CMC gel treated group was 59.17±2.69 (×104/mm3) and higher than the control 22.64±1.34 (×104/mm3) and CMC 2%-treated groups 40.80±5.27 (×104/mm3), respectively, P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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