| Autor: |
Roxana, Aguirre Castaneda, Nicole, Nader, Amy, Weaver, Ravinder, Singh, Seema, Kumar |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Hormone research in paediatrics. 78(4) |
| ISSN: |
1663-2826 |
| Popis: |
Vitamin D deficiency is highly prevalent in obese children, and obese children tend to respond poorly to vitamin D supplementation. The objective of the study was to compare the response to vitamin D(3) supplementation (2,000 IU once daily for 12 weeks) between obese and non-obese Caucasian adolescents.The study design was open label non-randomized. It was carried out at a single center. Eighteen obese adolescents (aged 12-18 years) and the same number of age-, gender- and season-matched non-obese adolescents received vitamin D(3) (2,000 IU/day) orally for 12 weeks. Total serum 25-hydroxyvitamin D [25(OH)D], parathyroid hormone, calcium and phosphorus were measured at baseline and at the end of the 12-week period.The mean baseline 25(OH)D level was higher in the non-obese compared to the obese subjects (mean 28.9 vs. 25.2 ng/ml; p = 0.029). The increment in 25(OH)D levels following vitamin D supplementation was significantly lower in the obese adolescents (mean change 5.8 vs. 9.8 ng/ml; p = 0.019).Higher doses of vitamin D are required to treat vitamin D deficiency in obese adolescents compared to their non-obese peers. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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