Neuroprotective effect of tanshinone IIA-incubated mesenchymal stem cells on Aβ

Autor:	Nanqu, Huang, Yuanyuan, Li, Yongjian, Zhou, Yanjun, Zhou, Fei, Feng, Shangpeng, Shi, Zhisheng, Ba, Yong, Luo
Rok vydání:	2018
Předmět:	Male Neurons Amyloid beta-Peptides Neuroimmunomodulation Tumor Necrosis Factor-alpha Mesenchymal Stem Cells Mesenchymal Stem Cell Transplantation Hippocampus Rats Rats Sprague-Dawley Disease Models Animal Neuroprotective Agents Alzheimer Disease Memory Abietanes Animals Learning
Zdroj:	Behavioural brain research. 365
ISSN:	1872-7549
Popis:	Mesenchymal stem cell transplantation can regulate neuroinflammation and treat Alzheimer's disease (AD), but its effect is attenuated by in vitro expansion. To solve this problem, we used tanshinone IIA (TIIA)-incubated mesenchymal stem cells (MSCs) to treat neuroinflammation caused by amyloid β-protein (Aβ). Here, we demonstrated that behavioral performance was rescued in rats receiving an intracerebroventricular injection of TIIA-incubated MSCs (TIIA-MSCs), and the TIIA-MSCs protected against neurotoxicity in the rat hippocampus by suppressing Aβ
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::8bb77ae642259fc4f04f314cbfa9f80a https://pubmed.ncbi.nlm.nih.gov/30831140 Zobrazit plný text záznamu Full Text from ScienceDirect