| Autor: |
Folake Lucy, Oyetayo, Seun Funmilola, Akomolafe, Funmilayo Olusola, Jegede, Olusola Olalekan, Elekofehinti, Moses Orimoloye, Akinjiyan, Ifeoluwa Adebayo, Odeniyi |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
J Diabetes Metab Disord |
| ISSN: |
2251-6581 |
| Popis: |
BACKGROUND: Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia resulting from insulin deficiency or dysfunction. The imbalance between free radicals and antioxidants known as oxidative stress has been implicated in the pathogenesis and complications associated with DM. Chrysophyllum albidum is a seasonal fruit found to be rich in natural antioxidants. METHODS: DM was induced by high-fat diet dietary supplementation for 14 days followed by intraperitoneal injection of streptozotocin (35 mg/kg). Thirty-five experimental rats were then divided into seven groups viz.: non-diabetic control; diabetic control; metformin; diabetic and non-diabetic fed with 5 and 10% C. albidum fruit pulp powder (CAFPP). Fasting blood glucose was done with an automatic auto-analyzer and weights were monitored at three-day intervals. The expressions of Nrf2, SOD, CAT, GST, TNF-α, DPP4, and insulin were investigated using RT-PCR. Schrödinger suites was used for docking of C. albidum phytocompounds with insulin. RESULTS: Diabetic rats fed with CAFPP for thirteen days have their blood glucose lowered significantly (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full text from SpringerLink