| Autor: |
Bozena, Piłacik, Teresa Wrońska, Nofer, Wojciech, Wasowicz |
| Rok vydání: |
2002 |
| Předmět: |
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| Zdroj: |
International journal of occupational medicine and environmental health. 15(1) |
| ISSN: |
1232-1087 |
| Popis: |
Isoprostanes are prostaglandin-like compounds that are produced by free radical mediated peroxidation of polyunsaturated fatty acids. There is a direct evidence showing that F2-isoprostanes can be utilized as a marker of lipid peroxidation due to the mechanism of their formation (nonenzymatic oxidation of arachidonic acid), chemical stability, sensitive and non-invasive methods of their estimation. An altered generation of F2-isoprostanes has been found in a variety of pathological syndromes associated with oxidative stress. Their quantification allows to elucidate the role of free radicals in oxidative injury. This paper reviews briefly the recent data on isoprostanes: biochemical mechanisms of their formation, methods of their measurement, and the possibilities of their utilization as a quantitative/qualitative marker of oxidative stress in vivo. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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