New Insight into the human genetic diversity in North African populations by genotyping of SNPs in DRD3, CSMD1 and NRG1 genes

Autor:	Souhir, Mestiri, Sami, Boussetta, Andrew J, Pakstis, Sarra, El Kamel, Amel, Ben Ammar El Gaaied, Kenneth K, Kidd, Lotfi, Cherni
Rok vydání:	2021
Předmět:	Genotype Haplotypes Neuregulin-1 Tumor Suppressor Proteins Receptors Dopamine D3 Black People Humans Membrane Proteins Polymorphism Single Nucleotide United States
Zdroj:	Molecular geneticsgenomic medicine. 10(3)
ISSN:	2324-9269 1010-8270
Popis:	The single nucleotide polymorphisms (SNPs) of the dopamine D3 receptor (DRD3), the CUB and sushi multiple domains 1 (CSMD1) and the neuregulin 1 (NRG1) genes were used to study the genetic diversity and affinity among North African populations and to examine their genetic relationships in worldwide populations.The rs3773678, rs3732783 and rs6280 SNPs of the DRD3 gene located on chromosome 3, the rs10108270 SNP of the CSMD1 gene and the rs383632, rs385396 and rs1462906 SNPs of the NRG1 gene located on chromosome 8 were analysed in 366 individuals from seven North African populations (Libya, Kairouan, Mehdia, Sousse, Kesra, Smar and Kerkennah).The low values of FThe Kairouan population exhibited a relatively low rate of genetic variability. The North African population has undergone significant gene flow but also evolutionary forces that have made it genetically distinct from other populations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::8b405f6e7b7961963df2f1ede322835b https://pubmed.ncbi.nlm.nih.gov/35128830 Zobrazit plný text záznamu Plný text