| Autor: |
Ahmad Khusairi, Azemi, Mohd Hafiz, Abd Rahim, Siti Syariah, Mamat, Abdul Manan, Mat Jais, Zainul Amiruddin, Zakaria |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Pakistan journal of pharmaceutical sciences. 31(1) |
| ISSN: |
1011-601X |
| Popis: |
Channa striatus (Haruan) is Malaysian freshwater fish that is traditionally used to treat ailments related to wound and also ulcers. The aimed of the present study was to determine the mechanisms of anti-ulcer activity of chloroform: methanol extract of C. striatus fillet (CMCS) in rats. The antiulcer profile of CMCS, given orally in the doses of 50, 250 and 500mg/kg, was assessed using the ethanol- and indomethacin-induced gastric ulcer models. The mechanisms of antiulcer of CMCS were determined as follows; i) the antisecretory activity of CMCS was measured using the pyloric ligation rat model, and; ii) the role of nitric oxide (NO) and sulfhydryl compounds in the modulation of CMCS antiulcer activity were determined by pre-treating the rats with |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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