| Autor: |
Karen, Pesqueda-Cendejas, Isela, Parra-Rojas, Mónica R, Meza-Meza, Paulina E, Mora-García, Bertha, Campos-López, Adolfo I, Ruiz-Ballesteros, Margarita, Montoya-Buelna, Melissa, Rivera-Escoto, José M, Moreno-Ortiz, Luis A, Bautista-Herrera, Sergio, Cerpa-Cruz, Ulises, De la Cruz-Mosso |
| Rok vydání: |
2022 |
| Zdroj: |
Clinical rheumatology. |
| ISSN: |
1434-9949 |
| Popis: |
Systemic lupus erythematosus (SLE) is an autoimmune disease where genetic factors have been related to SLE susceptibility and disease severity. CRP polymorphisms have been associated with high C-reactive protein (CRP) serum levels, cardiovascular disease (CVD), and high clinical disease activity in SLE patients; however, the evidence is still inconclusive.This study was aimed to assess the association of the - 717 A G, - 409 G A, + 1444 C T, and + 1846 C T CRP polymorphisms with genetic susceptibility, clinical disease activity, and CVD risk in Mexican-mestizo SLE patients.A comparative cross-sectional study was conducted on 369 unrelated women: 183 with SLE according to the 1997 SLE-ACR criteria and 186 healthy subjects (HS). The clinical disease activity was assessed by the Mex-SLEDAI score; CRP and lipid profile were quantified by turbidimetry and colorimetric-enzymatic assays, respectively. The CRP polymorphisms genotyping was carried out by allelic discrimination.SLE patients with - 717 AA genotype had higher CRP serum levels than SLE carriers of AG and GG genotypes (AA = 5 mg/L vs. AG = 3.2 mg/L vs. GG = 2.4 mg/L; p = 0.01), and the AA genotype was associated with high CVD risk by CRP in SLE patients (OR = 3; CI: 1.2-7.6; p 0.01).The - 717 A G CRP polymorphism is a risk factor for high CRP levels and high CVD risk in Mexican-mestizo SLE patients. Key Points • Cardiovascular disease is one of the major causes of death in SLE patients due to the higher prevalence of traditional and non-traditional cardiovascular risk factors. • C-reactive protein is a liver-derived acute-phase protein suggested as one powerful independent risk predictor factor for cardiovascular disease. • Single nucleotide polymorphisms in CRP have been suggested as genetic susceptibility factors that could modify the SLE pathophysiology outcomes. • Mexican-mestizo SLE patients carrying the -717 AG CRP AA genotype had 3-fold high cardiovascular disease risk than SLE patients with AG or GG genotypes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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