Release of human serum albumin from poly(lactide-co-glycolide) microspheres

Autor:	M S, Hora, R K, Rana, J H, Nunberg, T R, Tice, R M, Gilley, M E, Hudson
Rok vydání:	1990
Předmět:	Diffusion Molecular Weight Protein Denaturation Chemistry Pharmaceutical Polyesters Microscopy Electron Scanning Humans Electrophoresis Polyacrylamide Gel Buffers Polyglactin 910 Microspheres Serum Albumin
Zdroj:	Pharmaceutical research. 7(11)
ISSN:	0724-8741
Popis:	Human serum albumin (HSA) was encapsulated in a 50:50 copolymer of DL-lactide/glycolide in the form of microspheres. These microspheres were used as a model formulation to study the feasibility of controlling the release of large proteins over a 20- to 30-day period. We show that HSA can be successfully incorporated into microspheres and released intact from these microspheres into various buffer systems at 37 degrees C. A continuous release of the protein could be achieved in physiological buffers at 37 degrees C over a 20- to 30-day period from microspheres with high protein loadings (11.6%). These results demonstrate the potential of poly(DL-lactide-co-glycolide) microspheres for continuous delivery of large proteins.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::8b0852accd37c18f3414f40d42f788a7 https://pubmed.ncbi.nlm.nih.gov/2293220 Zobrazit plný text záznamu Full text from SpringerLink