| Autor: |
Fumi, Maeda, Shotaro, Gan, Azusa, Yamada, Daisuke, Kajiyama, Fumiaki, Tokitou, Machiko, Kawaguchi, Hidetoshi, Amagasa, Kazuo, Motoyama, Hideaki, Ganno, Kenichiro, Imai, Katsunori, Ami, Satoru, Iida, Akira, Fukuda, Masayuki, Ando, Yoshihiko, Okano |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Gan to kagaku ryoho. Cancerchemotherapy. 48(3) |
| ISSN: |
0385-0684 |
| Popis: |
Trifluridine/tipiracil (TAS-102) is an important chemotherapeutic agent recommended by the Japanese guidelines as third- or fourth-line treatment for colorectal cancer. Some studies have reported that administration of TAS-102 concomitant with bevacizumab prolongs progression-free and overall survival in colorectal cancer. We describe 2 patients treated with a chemotherapeutic regimen comprising TAS-102 concomitant with bevacizumab for recurrent colorectal cancer. No adverse events ≥Grade 3(except for hematotoxicity)were observed in these patients. The patient received several courses of chemotherapy with adjustments of the dose and dosing intervals to prevent neutropenia. Combination therapy using TAS-102 and bevacizumab is a feasible Late-line chemotherapeutic regimen for colorectal cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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