| Autor: |
Vinayak, Singh, Anna E, Grzegorzewicz, Stephen, Fienberg, Rudolf, Müller, Lutete Peguy, Khonde, Olalla, Sanz, Salvatore, Alfonso, Beatriz, Urones, Gerard, Drewes, Marcus, Bantscheff, Sonja, Ghidelli-Disse, Thomas R, Ioerger, Bhanupriya, Angala, Jiuyu, Liu, Richard E, Lee, James C, Sacchettini, Inna V, Krieger, Mary, Jackson, Kelly, Chibale, Sandeep R, Ghorpade |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
ACS infectious diseases. 8(11) |
| ISSN: |
2373-8227 |
| Popis: |
Alternative mode-of-inhibition of clinically validated targets is an effective strategy for circumventing existing clinical drug resistance. Herein, we report 1,3-diarylpyrazolyl-acylsulfonamides as potent inhibitors of HadAB/BC, a 3-hydroxyl-ACP dehydratase complex required to iteratively elongate the meromycolate chain of mycolic acids in |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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