NOX1-derived ROS drive the expression of Lipocalin-2 in colonic epithelial cells in inflammatory conditions

Autor:	Nesrine, Makhezer, Marwa, Ben Khemis, Dan, Liu, Yamina, Khichane, Viviana, Marzaioli, Asma, Tlili, Marjan, Mojallali, Coralie, Pintard, Philippe, Letteron, Margarita, Hurtado-Nedelec, Jamel, El-Benna, Jean-Claude, Marie, Aurélie, Sannier, Anne-Laure, Pelletier, Pham My-Chan, Dang
Rok vydání:	2018
Předmět:	Mice Knockout Colon Tumor Necrosis Factor-alpha Interleukin-17 NADPH Oxidases Colitis Cytochrome b Group Inflammatory Bowel Diseases p38 Mitogen-Activated Protein Kinases Immunity Innate Mice Gene Expression Regulation Lipocalin-2 Trinitrobenzenesulfonic Acid NADPH Oxidase 1 Animals Cytokines Humans Intestinal Mucosa RNA Small Interfering Reactive Oxygen Species Cells Cultured Signal Transduction
Zdroj:	Mucosal immunology. 12(1)
ISSN:	1935-3456
Popis:	Inflammatory bowel disease (IBD) is characterized by severe and recurrent inflammation of the gastrointestinal tract, associated with altered patterns of cytokine synthesis, excessive reactive oxygen species (ROS) production, and high levels of the innate immune protein, lipocalin-2 (LCN-2), in the mucosa. The major source of ROS in intestinal epithelial cells is the NADPH oxidase NOX1, which consists of the transmembrane proteins, NOX1 and p22
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::8abc0b0d578d1e0991c73058d5659185 https://pubmed.ncbi.nlm.nih.gov/30279516 Zobrazit plný text záznamu Full text from SpringerLink