| Autor: |
Fang, Yang, Xiaojuan, Chen, Xiaojuan, Song, Raquel, Ortega, Xiaojing, Lin, Wuqing, Deng, Jing, Guo, Zhengchao, Tu, Adam V, Patterson, Jeff B, Smaill, Yongheng, Chen, Xiaoyun, Lu |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of medicinal chemistry. 65(21) |
| ISSN: |
1520-4804 |
| Popis: |
The FGF19-FGFR4 signaling pathway has been extensively studied as a promising target for the treatment of hepatocellular carcinoma (HCC). Several FGFR4-selective inhibitors have been developed, but none of them receives approval. Additionally, acquired resistance caused by FGFR4 gatekeeper mutations is emerging as a serious limitation for these targeted therapies. Herein, we report a novel series of 5-formyl-pyrrolo[3,2 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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