[Non-radioactive in situ hybridization of alpha-satellite sequences in cytogenetic diagnosis]
| Autor: | C, Perfumo, A, Arslanian, F, Zara, G, Piombo, M, Pierluigi |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Chromosome Aberrations Genetic Markers Male Chromosomes Human Pair 15 Chromosomes Human Pair 21 Chromosomes Human Pair 20 Infant Newborn Chromosome Disorders Dwarfism Oligospermia DNA Satellite Translocation Genetic Abortion Spontaneous Pregnancy Y Chromosome Humans Female Down Syndrome Child DNA Probes In Situ Hybridization Fluorescence |
| Zdroj: | Pathologica. 84(1091) |
| ISSN: | 0031-2983 |
| Popis: | Non isotopic in situ hybridization with alpha-satellite DNA probes in the cytogenetic diagnosis. Standard banding cytogenetic techniques do not always allow to define the structure and the origin of chromosome rearrangements involving the centromere region. Non-isotopic in situ hybridization of alphoid sequences has allowed to determine the origin of the centromeres in the metaphases of 5 patients referred to us for: 2 structural rearrangements involving chromosome 21, 2 structural rearrangements involving chromosome Y and 1 reciprocal translocation involving on chromosome 20 and one chromosome 15. |
| Databáze: | OpenAIRE |
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