[Activation of the blood kallikrein-kinin system in disseminated intravascular coagulation in rats. The significance of the pulmonary component and an attempt at correction with aspirin]

Autor:	G N, Meshcheriakov, O A, Gomazkov
Rok vydání:	1984
Předmět:	Male Aspirin Drug Evaluation Preclinical Thrombin Rats Inbred Strains Kinins Disseminated Intravascular Coagulation Antifibrinolytic Agents Rats Enzyme Activation para-Aminobenzoates Animals Kallikreins 4-Aminobenzoic Acid Lung
Zdroj:	Biulleten' eksperimental'noi biologii i meditsiny. 98(9)
ISSN:	0365-9615
Popis:	It has been shown that the development in animals of disseminated intravascular coagulation (DIC) caused by long-term intravenous infusion of thrombin was accompanied by appreciable activation of the kallikrein-kinin system, being characteristic of acute pathological processes. In the initial stages of the process development, prekallikrein and kallikrein inhibitor were observed to be secreted from the lungs to arterial blood. Further development of DIC led to the depletion of the reserves of the kinin system. Pretreatment with a single low dose of acetylsalicylic acid considerably reduced the total animals' lethality and postponed blood kinin system activation determined by the development of DIC.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::8a72d83c06def2e245914ae450bab067 https://pubmed.ncbi.nlm.nih.gov/6333254 Zobrazit plný text záznamu