Regulation of chondrocyte growth and differentiation by fibroblast growth factor receptor 3

Autor:	D M, Ornitz
Rok vydání:	2001
Předmět:	Bone Development Sequence Homology Amino Acid Molecular Sequence Data Cell Differentiation Dwarfism Osteochondrodysplasias Fibroblast Growth Factors Craniosynostoses Chondrocytes Animals Humans Amino Acid Sequence Sequence Alignment Cell Division Conserved Sequence
Zdroj:	Novartis Foundation symposium. 232
ISSN:	1528-2511
Popis:	Both gain-of-function and loss-of-function mutations in fibroblast growth factor receptor 3 (Fgfr3) have revealed unique roles for this receptor during skeletal development. Loss-of-function alleles of Fgfr3 lead to an increase in the size of the hypertrophic zone, delayed closure of the growth plate and the subsequent overgrowth of long bones. Gain-of-function mutations in Fgfr3 have been genetically linked to autosomal dominant dwarfing chondrodysplasia syndromes where both the size and architecture of the epiphyseal growth plate are altered. Analysis of these phenotypes and the biochemical consequences of the mutations in FGFR3 demonstrate that FGFR3-mediated signalling is an essential negative regulator of endochondral ossification.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::8a721c70803898a711166a1e5288e724 https://pubmed.ncbi.nlm.nih.gov/11277088 Zobrazit plný text záznamu