Combined effects of cyclosporin and nifedipine on gingival overgrowth in rats is not age dependent

Autor:	L C, Spolidorio, D M, Spolidorio, C, Benatti, J E, Sampaio, O P, Almeida
Rok vydání:	2003
Předmět:	Male Analysis of Variance Nifedipine Gingival Overgrowth Age Factors Drug Synergism Calcium Channel Blockers Epithelium Rats Drug Combinations Connective Tissue Cyclosporine Animals Rats Wistar Immunosuppressive Agents
Zdroj:	Journal of periodontal research. 38(4)
ISSN:	0022-3484
Popis:	Cyclosporin A and nifedipine cause gingival overgrowth in rat, and the combined use of these drugs increases the overgrowth severity.The purpose of this study was to compare gingival overgrowth of rats of differents ages treated with cyclosporin A and nifedipine alone or given concurrently.Rats 15, 30, 60 and 90 d old were treated with 10 mg/kg body weight of cyclosporin A and/or 50 mg/kg body weight of nifedipine in the chow.Young rats showed evident gingival overgrowth with nifedipine, cyclosporin A, and cyclosporin A and nifedipine given concurrently. Adult rats did not show significant gingival alterations when treated with cyclosporin A and nifedipine alone. Nevertheless evident gingival overgrowth with alterations of the epithelium and connective tissue were observed when treated simultaneously with cyclosporin A and nifedipine.These results suggest that the combined effects of cyclosporin A and nifedipine on gingival overgrowth in rat is not age dependent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::8a64b17a9bbc44bca11d6c5d0f09b0e4 https://pubmed.ncbi.nlm.nih.gov/12828653 Zobrazit plný text záznamu Plný text