ANP, BNP and D-dimer predict right ventricular dysfunction in patients with acute pulmonary embolism
| Autor: | Henrik, Gutte, Jann, Mortensen, Claus V, Jensen, Peter, von der Recke, Claus L, Petersen, Ulrik S, Kristoffersen, Andreas, Kjaer |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Denmark Perfusion Imaging Ventricular Dysfunction Right Fibrin Fibrinogen Degradation Products Predictive Value of Tests Natriuretic Peptide Brain Odds Ratio Humans Prospective Studies Aged Aged 80 and over Tomography Emission-Computed Single-Photon Endothelin-1 Troponin I Middle Aged Prognosis Up-Regulation Logistic Models ROC Curve Acute Disease Linear Models Ventricular Function Right Female Pulmonary Embolism Tomography X-Ray Computed Atrial Natriuretic Factor Biomarkers |
| Zdroj: | Clinical physiology and functional imaging. 30(6) |
| ISSN: | 1475-097X |
| Popis: | The aim of this study was to predict right ventricular dysfunction (RVD) using plasma concentration of D-dimer, pro-atrial natriuretic peptide (pro-ANP), brain natriuretic peptide (BNP), endothelin-1 (ET-1) and cardiac troponin I (TNI) in patients with pulmonary embolism (PE).Patients suspected of PE had a ventilation/perfusion-single-photon emission-tomography (V/Q-SPECT), pulmonary multidetector computer tomography (MDCT) angiography, blood samples and ECG-gated cardiac CT performed the same day.Pro-ANP, BNP and D-dimer are associated with significantly elevated levels in PE patients with RVD. ROC curves demonstrated that D-dimer, pro-ANP and BNP were accurate for detection of RVD.Because measurements of cardiac biomarkers are inexpensive and easily obtained they may prove useful in the clinical diagnosis of RVD. However because of the small sample size, the results need to be confirmed in larger studies. |
| Databáze: | OpenAIRE |
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