Characterization of the
| Autor: | Joakim, Håkansson, Lovisa, Ringstad, Anita, Umerska, Jenny, Johansson, Therese, Andersson, Lukas, Boge, René T, Rozenbaum, Prashant K, Sharma, Petter, Tollbäck, Camilla, Björn, Patrick, Saulnier, Margit, Mahlapuu |
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| Rok vydání: | 2019 |
| Předmět: |
DPK-060
Staphylococcus aureus lipid nanocapsules Swine Administration Topical Microbial Sensitivity Tests Poloxamer Protein Serine-Threonine Kinases Staphylococcal Infections Skin Irritancy Tests Lipids Anti-Bacterial Agents skin infections Disease Models Animal Mice antimicrobial peptides Cellular and Infection Microbiology Nanocapsules Animals Female Staphylococcal Skin Infections cubosomes Antimicrobial Cationic Peptides Original Research |
| Zdroj: | Frontiers in Cellular and Infection Microbiology |
| ISSN: | 2235-2988 |
| Popis: | Antimicrobial peptides, also known as host defense peptides, have recently emerged as a promising new category of therapeutic agents for the treatment of infectious diseases. This study evaluated the preclinical in vitro, ex vivo, and in vivo antimicrobial activity, as well as the potential to cause skin irritation, of human kininogen-derived antimicrobial peptide DPK-060 in different formulations designed for topical delivery. We found that DPK-060 formulated in acetate buffer or poloxamer gel caused a marked reduction of bacterial counts of Staphylococcus aureus in vitro (minimum microbicidal concentration |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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