Neuroprotective Activities of Granulocyte-Macrophage Colony Stimulating Factor Following Controlled Cortical Impact
| Autor: | Kelso, Matthew L., Elliott, Bret R., Haverland, Nicole A., Mosley, R. Lee, Gendelman, Howard E. |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Cerebral Cortex
Male Analysis of Variance Granulocyte-Macrophage Colony-Stimulating Factor Nerve Tissue Proteins Flow Cytometry Microarray Analysis T-Lymphocytes Regulatory Article Functional Laterality nervous system diseases Mice Inbred C57BL Disease Models Animal Mice Gene Expression Regulation Brain Injuries Animals Cytokines Lymphocytes Protein Interaction Maps |
| Popis: | Neurodegeneration after traumatic brain injury is facilitated by innate and adaptive immunity and can be harnessed to affect brain repair. In mice subjected to controlled cortical impact (CCI), we show that treatment with granulocyte macrophage colony stimulating factor (GM-CSF) affects regulatory T cell numbers in the cervical lymph nodes coincident with decreased lesion volumes and increased cortical tissue sparing. This paralleled increases in neurofilament and diminished reactive microglial staining. Transcriptomic analysis showed that GM-CSF induces robust immune neuroprotective responses seven days following CCI. Together, these results support the therapeutic potential of GM-CSF for TBI. |
| Databáze: | OpenAIRE |
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