| Autor: |
Gustavo, Capistrano, Harley F, Rodrigues, Nicholas, Zufelato, Cristhiane, Gonçalves, Clever G, Cardoso, Elisangela P, Silveira-Lacerda, Andris F, Bakuzis |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 37(3) |
| ISSN: |
1464-5157 |
| Popis: |
Noninvasive thermometry during magnetic nanoparticle hyperthermia (MNH) remains a challenge. Our pilot study proposes a methodology to determine the noninvasive intratumoral thermal dose during MNH in the subcutaneous tumor model.Two groups of Ehrlich bearing-mice with solid and subcutaneous carcinoma, a control group (One animal of the MNH group showed tumor recurrence, while two others showed complete tumor remission (monitored for 585 days). Sensitivity analysis of the simulation parameters indicated low tumor blood perfusion. Numerical simulations indicated, for the animals with complete remission, an irreversible tissue injury of 91 ± 5% and 100%, while the one with recurrence had a lower value, 56 ± 7%. The computer simulations also revealed theA new methodology for determining noninvasively the three-dimensional intratumoral thermal dose during MNH was developed. The method demonstrates the potential for predicting the long-term preclinical outcome of animals treated with MNH. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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