| Autor: |
M, Morroni, G, Barbatelli, V, Carboni, A, Sbarbati, S, Cinti |
| Rok vydání: |
1995 |
| Předmět: |
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| Zdroj: |
Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology. 9(3) |
| ISSN: |
0921-8912 |
| Popis: |
Electron spectroscopic imaging (ESI) is a recent tool for electron microscopic analysis which permits the recognition of the distribution of elements in a specimen, with a spatial resolution up to 5 nm. The authors performed the ESI together with X-ray microanalysis (EDX) and transmission electron microscopy to study granulomatous subcutaneous nodules in a patient who had undergone a desensitising therapy with an aluminium-containing vaccine. Aluminium was detected both by EDX and ESI, mainly in lysosomes of histiocytes containing needle-shaped material in a lucent matrix. However, ESI provided a better localization of aluminium with respect to EDX. This result suggests that the identification of aluminium-containing structures cannot be obtained only by ultrastructural morphology and underlines the utility of a microanalitycal study for a correct diagnosis in the presence of a needle-shaped deposition of dense material in lysosomes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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