Randomized Controlled Trial of a Remote Coaching mHealth Adherence Intervention in Youth Living with HIV

Autor: K Rivet, Amico, Jane C, Lindsey, Michael, Hudgens, Ronald, Dallas, Keith J, Horvath, Amanda, Dunlap, Rachel, Goolsby, Megan Mueller, Johnson, Barbara, Heckman, Jessica, Crawford, Elizabeth, Secord, Murli, Purswani, Danial, Reirden, Mobeen, Rathore, Lisa-Gaye, Robinson, Aditya H, Gaur
Rok vydání: 2022
Předmět:
Zdroj: AIDS and behavior. 26(12)
ISSN: 1573-3254
Popis: Youth living with HIV (YLWH) in the US have low rates of viral suppression (VS). In a prospective randomized clinical trial (ATN152) that enrolled 89 YLWH on antiretroviral therapy (ART) with detectable viral load, we evaluated a 12 week triggered escalating real-time adherence (TERA) intervention with remote coaching, electronic dose monitoring (EDM), and outreach for missed/delayed doses compared to standard of care (SOC). Median [Q1, Q3] percent days with EDM opening was higher in TERA (72% (47%, 89%)) versus SOC (41% (21%, 59%); p 0.001) and incidence of numbers of 7 day gaps between openings were lower (TERA to SOC ratio: 0.40; 95% CI 0.30, 0.53; p 0.001). There were no differences in VS at week 12 (TERA 35%; 95% CI 21%, 51% versus SOC 36%; 95% CI 22%, 51%; p 0.99) or later time-points. The intervention improved adherence but not VS in heavily ART-experienced YLWH. Remote coaching more closely tailored to the unique dosing patterns and duration of need for youth struggling to reach VS warrants further investigation.
Databáze: OpenAIRE
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