| Autor: |
A, Kreil, C, Wenisch, G, Brittenham, S, Looareesuwan, M, Peck-Radosavljevic |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
British journal of haematology. 109(3) |
| ISSN: |
0007-1048 |
| Popis: |
Thrombopoietin (TPO) is the key growth factor for platelet production and is elevated in states of platelet depletion. As thrombocytopenia is a common finding in malaria, we analysed TPO regulation before, during and after antimalarial treatment. Before treatment, TPO serum levels were significantly higher in patients with severe malaria (n = 35) than in patients with uncomplicated malaria (n = 44; P = 0.024), normalizing within 14-21 d of therapy. The rapid normalization of TPO levels and increase in low peripheral platelet counts after treatment indicate that the biosynthesis of TPO and its regulation in malaria patients are normal. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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