Variant in CAPN10 gene and environmental factors show evidence of association with excess weight among young people in a Colombian population
| Autor: | Ana C, Orozco, Angélica M, Muñoz, Claudia M, Velásquez, Rosa M, Uscátegui, María V, Parra, Fredy A, Patiño, Luz M, Manjarrés, Beatriz E, Parra, Alejandro, Estrada, Gloria M, Agudelo |
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| Rok vydání: | 2014 |
| Předmět: |
Dietary Fiber
Male Adolescent Genotype Alpha-Ketoglutarate-Dependent Dioxygenase FTO Colombia Motor Activity Polymorphism Single Nucleotide Ion Channels Mitochondrial Proteins Leisure Activities Surveys and Questionnaires Humans Uncoupling Protein 3 Genetic Predisposition to Disease Obesity Child Adiposity Anthropometry Calpain Proteins Overweight Diet Cross-Sectional Studies Video Games Fast Foods Female Gene-Environment Interaction Television Sedentary Behavior |
| Zdroj: | Biomedica : revista del Instituto Nacional de Salud. 34(4) |
| ISSN: | 2590-7379 |
| Popis: | Introduction : Obesity results from interaction between genetic and environmental risk factors.To evaluate the effect of three gene variants and environmental factors on obesity and overweight in young people aged 10 to 18 years in a Colombian population.A total of 424 subjects were selected and separated into three groups for a cross-sectional study; 100 obese and 112 overweight subjects were matched with 212 normal-weight controls. Associations were evaluated between excess weight and three genetic polymorphisms ( UCP3- rs1800849, FTO -rs17817449, and CAPN10 -rs3842570), as well as the family history, the time spent watching television and playing video games, and the diet.A family history of obesity, the time spent watching television and playing video games, the lack of breastfeeding, a low consumption of cereals, legumes, fruits, vegetables, and a high consumption of fast foods were characteristics typically found in obese individuals compared to controls. A significant association between genotype I/I (SNP19 of CAPN10 ) and excess weight was found even with an active lifestyle. In addition, significant associations between the C/C genotype of the UCP3 gene and the G/G and T/T genotypes of the FTO gene and excess weight were found only in young sedentary individuals.In this population, inadequate diet and sedentary lifestyle increased the risk of excess weight. Genotype I/I of SNP19 in CAPN10 was significantly associated with excess weight. In contrast, FTO and UCP3 variants exhibited effects only in sedentary environments. |
| Databáze: | OpenAIRE |
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