Onset of sex differentiation: dialog between genes and cells
| Autor: | H, Merchant-Larios, N, Moreno-Mendoza |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Fetal Proteins
Male Sex Differentiation Kruppel-Like Transcription Factors Models Biological Mice Cell Movement Y Chromosome Testis Animals Humans Cell Lineage Castration Genes sry Mullerian Ducts Homeodomain Proteins Mammals Mice Knockout Stem Cell Factor Sertoli Cells Ovary Gene Expression Regulation Developmental Leydig Cells Nuclear Proteins Cell Differentiation Wolffian Ducts Sex Determination Processes Sex-Determining Region Y Protein DNA-Binding Proteins Proto-Oncogene Proteins c-kit Germ Cells Phenotype Seminiferous Epithelium Female Stromal Cells Transcription Factors |
| Zdroj: | Archives of medical research. 32(6) |
| ISSN: | 0188-4409 |
| Popis: | During the late 1940s, Alfred Jost demonstrated that mammalian sex differentiation begins in fetal testis, producing two factors necessary for the establishment of phenotypic males. Castrated embryos prior to testis differentiation led to phenotypic female differentiation. Jost proposed the existence of a testis-determining factor (TDF), elucidated in 1990 and named SRY for humans and Sry for mice. Thereafter, an increasing list of genes expressed in the genital ridges of mouse embryos at the onset of gonad differentiation has appeared. To date, it is clear that complete understanding of the mechanisms underlying gonadal sex differentiation in mammals requires identification of key cell lineages in which gonadal-specific genes are expressed. Here, a correlation between known gene expression and gonadal morphologic changes is attempted. |
| Databáze: | OpenAIRE |
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