| Autor: |
Iu P, Taran, L N, Shishkina, L S, Evseenko, G V, Kukushkina |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Patologicheskaia fiziologiia i eksperimental'naia terapiia. (1) |
| ISSN: |
0031-2991 |
| Popis: |
The effects of 6-methyluracil given in single intraperitoneal doses of 50 and 2.7 mg/kg on the healing of burn wounds and some physicochemical parameters of lipid peroxidation regulation were studied in the liver and erythrocytes of noninbred albino rats with thermal burns. 6-Methyluracil was shown to alter the time course of a wound process and to accelerate the healing of burn wounds. The drug doses under study were found to exert a great effect on the level of lipid antioxidative activity and the composition of phospholipids of the liver and erythrocytes, which remained for a long time after burn. The findings suggest the hypothesis that the capacity of 6-methyluracil to be involved in the regulation of lipid peroxidation processes underlies its therapeutic effect. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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