Decreased BDNF signalling in transgenic mice reduces epileptogenesis
| Autor: | Sari, Lähteinen, Asla, Pitkänen, Tommi, Saarelainen, Jari, Nissinen, Eija, Koponen, Eero, Castrén |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Epilepsy Neuronal Plasticity Brain-Derived Neurotrophic Factor Growth Cones Action Potentials Down-Regulation Mice Transgenic Mice Epilepsy Temporal Lobe Dentate Gyrus Mossy Fibers Hippocampal Nerve Degeneration Excitatory Amino Acid Agonists Animals Receptor trkB Female Neuropeptide Y Signal Transduction |
| Zdroj: | The European journal of neuroscience. 15(4) |
| ISSN: | 0953-816X |
| Popis: | Brain derived neurotrophic factor (BDNF) has been suggested to be involved in epileptogenesis. Both pro- and antiepileptogenic effects have been reported, but the exact physiological role is still unclear. Here, we investigated the role of endogenous BDNF in epileptogenesis by using transgenic mice overexpressing truncated trkB, a dominant negative receptor of BDNF. After induction of status epilepticus (SE) by kainic acid, the development of spontaneous seizures was monitored by video-EEG system. Hilar cell loss, and the number of neuropeptide Y immunoreactive cells were studied as markers of cellular damage, and mossy fibre sprouting was investigated as a plasticity marker. Our results show that transgenic mice had significantly less frequent interictal spiking than wild-type mice, and the frequency of spontaneous seizures was lower. Furthermore, compared to wild-type animals, transgenic mice had less severe seizures with later onset and mortality was lower. In contrast, no differences between genotypes were observed in any of the cellular or plasticity markers. Our results suggest that transgenic mice with decreased BDNF signalling have reduced epileptogenesis. |
| Databáze: | OpenAIRE |
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