A Pilot Dose-Finding Study of Etanercept in Rheumatoid Arthritis
Autor: | Ferdinand C, Breedveld, Heather E, Jones, Kim, Peifer, Joan, Korth-Bradley |
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Rok vydání: | 2017 |
Předmět: |
Adult
Male United States Food and Drug Administration Research Guidelines as Topic Pilot Projects Articles Middle Aged Drug Administration Schedule United States Article Etanercept Arthritis Rheumatoid Placebos Treatment Outcome Double-Blind Method Drug Development Antirheumatic Agents Humans Female Prospective Studies Aged Randomized Controlled Trials as Topic |
Zdroj: | Clinical and Translational Science |
ISSN: | 1752-8062 |
Popis: | A randomized, parallel‐dose study assessed the pharmacokinetics (PK) and pharmacodynamics (PD) of etanercept in 61 patients with rheumatoid arthritis (RA) who received doses from 10 mg once‐weekly to 50 mg twice‐weekly for 4 weeks. Empiric application of a maximal‐effect (Emax) model to pooled steady‐state concentrations (Css) and PD markers provided half‐maximal‐effect concentration estimates of 567, 573, 465, 87, and 159 ng/mL for change from baseline in number of swollen joints, number of painful joints, erythrocyte sedimentation rate, interleukin‐6, and matrix metalloproteinase‐3, respectively. Css >∼2,000 ng/mL did not appear to offer additional benefit. It was concluded that the middle doses, 10 mg twice‐weekly, 50 mg every 2 weeks, and 50 mg once‐weekly, would provide Css in the target range of 500–2,000 ng/mL. The revised US Food and Drug Administration guideline for development of medicines for treatment of RA encourages a study design incorporating PK/PD assessment to inform later studies. |
Databáze: | OpenAIRE |
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