| Autor: |
Gustavo Henrique, da Silva, Almerinda Vieira Fernandes Ribeiro, Alves, Pedro, Duques, Tiago, Sevá-Pereira, Elza Cotrim, Soares, Cecilia Amelia Fazzio, Escanhoela |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Journal of gastrointestinal and liver diseases : JGLD. 19(2) |
| ISSN: |
1841-8724 |
| Popis: |
A case of enalapril-induced acute hepatotoxicity with an unusual morphology is described. This morphology was characterized by macro- and microvesicular steatosis associated with neutrophil infiltration and Mallory bodies, occasionally with satellitosis. These alterations were most abundant in zone 1 of the periportal region, less common in zone 2 and rare in zone 3. There was also confluent periportal necrosis with sinusoidal fibrin deposits associated with intense ductal metaplasia and an infiltrate of inflammatory cells that included plasmocytes and a few eosinophils, as well as focal biliary damage. This morphology, that may be referred as "predominantly periportal steatohepatitis", was distinct from that associated with non-alcohol and alcohol-induced steatohepatitis, both initiated in acinar zone 3 and subsequently extended to other zones. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
