| Autor: |
David, Grimwade, Susan V, Outram, Rajinder, Flora, Stuart J, Ings, Arnold R, Pizzey, Ricardo, Morilla, Charles F, Craddock, David C, Linch, Ellen, Solomon |
| Rok vydání: |
2002 |
| Předmět: |
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| Zdroj: |
Cancer research. 62(16) |
| ISSN: |
0008-5472 |
| Popis: |
The nature of hemopoietic progenitors subject to leukemic transformation in acute myeloid leukemia (AML) has not been clearly defined. To address this issue, we have used DNase I hypersensitivity assays to study the chromatin structure surrounding the T-lineage-affiliated CD2 gene in the acute promyelocytic subtype of AML (APL). Upstream and downstream flanking regions of CD2 were found to be hypersensitive to DNase I in primary APL blasts, with an identical pattern of hypersensitive sites to those detected in cells of T-lineage. All of the sites were confirmed to be inaccessible to DNase I in B-lineage leukemia cells. The demonstration of T-cell-associated chromatin features in primary APL blasts has implications for the origin of APL that may arise in more primitive progenitors than previously considered to be the case. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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