Cytogenetic findings in familial B-cell chronic lymphocytic leukemia: a report of two cases in a family

Autor:	Blanca, Espinet, Marta, Salido, José Angel, Hernández, Lurdes, Zamora, M Alba, Bosch, Sergi, Serrano, Francesc, Solé
Rok vydání:	2003
Předmět:	Chromosome Aberrations Male Siblings Chromosomes Human Humans Female Middle Aged Leukemia Lymphocytic Chronic B-Cell Gene Deletion In Situ Hybridization Fluorescence
Zdroj:	Cancer genetics and cytogenetics. 143(2)
ISSN:	0165-4608
Popis:	Familial B-cell chronic lymphocytic (B-CLL) leukemia has been defined as an entity epidemiologically different from sporadic B-CLL. Cytogenetic abnormalities in familial B-CLL, studied either by conventional cytogenetics or by interphase fluorescence in situ hybridization (i-FISH), have rarely been reported. We report a two-case family affected with B-CLL showing two different abnormal karyotypes detected by conventional cytogenetics [46,XX,del(7)(q32) and 46,XY,add(1)(p36),del(6)(q21)] but sharing a del(13)(q14) at the D13S319 locus, detected by interphase fluorescence in situ hybridization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::88f27e426b3ae198baabb34922879d49 https://pubmed.ncbi.nlm.nih.gov/12781453 Zobrazit plný text záznamu Full Text from ScienceDirect