[Diagnosis of heterozygote carrier of mutant gene of 21-hydroxylase]

Autor: I G, Dzenis, T N, Iudina, E K, Brykova, V A, Bakharev, N D, Fanchenko
Rok vydání: 1995
Předmět:
Zdroj: Akusherstvo i ginekologiia. (1)
ISSN: 0300-9092
Popis: Heterozygotic carriers of 21-hydroxylase deficiency were detected by prolonged ACTH stimulation test. Stepwise discriminant analysis was used for data processing, which helped derive a function: D = 0.052 x X1 + 0.05 x X2 -0.018 x X3 = 0.069, where X1 is 17-hydroxylase concentration 9 h after ACTH infusion, X2 ratio of basel hydrocortisone concentrations to 17-hydroxylase, and X3 ratio of hydrocortisone concentrations to 17-hydroxylase 9 h after ACTH of infusion. Clinical efficacy of detection of heterozygotic carriers was 85%.
Databáze: OpenAIRE