| Autor: |
R, Chammas, M G, Jasiulionis, A M, Ventura, L R, Travassos, R R, Brentani |
| Rok vydání: |
1996 |
| Předmět: |
|
| Zdroj: |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 29(9) |
| ISSN: |
0100-879X |
| Popis: |
Malignant transformation is accompanied by changes in cell-matrix interactions. Upon transfection with EJ-ras oncogene, transformed fibroblasts acquired a migratory phenotype towards laminin-1. The increase in integrin expression was responsible for the migratory activity of transformed fibroblasts. In addtion alpha 6 beta 1 integrins, both galectin-3 and an unidentified laminin-binding polypeptide had their expression pattern altered upon transformation. Here, we review these two classes of laminin-binding proteins and their possible roles in cell-laminin interactions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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