Systemic inflammatory markers as independent prognosticators of head and neck squamous cell carcinoma
| Autor: | Alipasha, Rassouli, Joe, Saliba, Roberto, Castano, Michael, Hier, Anthony G, Zeitouni |
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| Rok vydání: | 2013 |
| Předmět: |
Aged
80 and over Male Neutrophils Platelet Count Squamous Cell Carcinoma of Head and Neck Middle Aged Disease-Free Survival Survival Rate Head and Neck Neoplasms Predictive Value of Tests Carcinoma Squamous Cell Humans Female Lymphocyte Count Neoplasm Recurrence Local Biomarkers Aged Retrospective Studies |
| Zdroj: | Headneck. 37(1) |
| ISSN: | 1097-0347 |
| Popis: | The purpose of this study was to investigate the prognostic value of the pretreatment inflammatory markers platelet-to-lymphocyte ratio (PLR) and the neutrophil-to-lymphocyte ratio (NLR) in patients with head and neck squamous cell carcinoma (HNSCC).We conducted a retrospective analysis of patients diagnosed with HNSCC at McGill University Health Center from 2000 to 2011 (273 patients were retained). Hematologic parameters were recorded within 4 weeks of diagnosis. Mortality and recurrence rates were compared according to various PLR and NLR thresholds.Of the total patients, 20.5% died and 11.0% had disease recurrence. PLR170 was associated with higher mortality (p = .008). The subgroup with a combination of PLR170 and NLR ≤3.0 was associated with higher T classification and highest mortality (43%). NLR above 4.2 predicted higher rates of recurrence (p.0001). The NLR/PLR combination was at least as good as TNM staging in predicting survival.PLR is an independent predictor of mortality; NLR is an independent predictor of recurrence in HNSCC. These parameters might be used to identify advanced stages rapidly and economically. |
| Databáze: | OpenAIRE |
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