| Autor: |
Jackson, Monteiro, Luiz Felipe D, Passero, Jéssica A, Jesus, Márcia D, Laurenti, João H G, Lago, Marisi G, Soares, Andrea N L, Batista, João M, Batista, Patricia, Sartorelli |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Current topics in medicinal chemistry. 22(19) |
| ISSN: |
1873-4294 |
| Popis: |
The fractionation of the n-hexane phase of the EtOH extract from the leaves of Duguetia lanceolata (Annonaceae) led to the identification of the sesquiterpene (-)-cyclocolorenone.Chemical characterization, including determination of the absolute stereochemistry, and in vitro evaluation of antileishmanial activity of the sesquiterpene (-)-cyclocolorenone, isolated from D. lanceolata, were carried out.(-)-Cyclocolorenone was isolated from D. lanceolata leaves using different chromatographic steps and its structure was defined by analysis of NMR and ESI-HRMS data. Additionally, the absolute configuration of (-)-cyclocolorenone was ambiguously assigned by means of vibrational circular dichroism (VCD). Antileishmanial activity of (-)-cyclocolorenone was evaluated on promastigote and amastigote forms of Leishmania (Leishmania) amazonensis. The integrity of the cell membrane of L. (L.) amazonensis was analyzed using the SYTOX green probe.(-)-(1R,6S,7R,10R)-Cyclocolorenone displayed activity against promastigotes and amastigotes forms of L. (L.) amazonensis with ICObtained data suggested that (-)-cyclocolorenone, in which absolute configuration was determined, can be considered as a scaffold for the development of new drugs for the treatment of leishmaniasis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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