| Autor: |
J R, Johnson, D K, Myers, J S, Jackson, D W, Dunford, N J, Gragtmans, H M, Wyatt, A R, Jones, D H, Percy |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Radiation research. 144(1) |
| ISSN: |
0033-7587 |
| Popis: |
To help resolve uncertainties as to the most appropriate weighting factor for tritium beta rays, a large experiment was carried out to measure the relative biological effectiveness (RBE) of tritiated water compared to X rays for the induction of myeloid leukemia in male mice of the CBA/H strain. The study was designed to estimate the lifetime incidence of myeloid leukemia in seven groups of about 750 mice each; radiation exposures were approximately 0, 1, 2 and 3 Gy both for tritiated water and for X rays. The lifetime incidence of leukemia in these mice increased from 0.13% in the control group to 6-8% in groups exposed to higher radiation doses. The results were fitted to various equations relating leukemia incidence to radiation dose, using both the raw data and data corrected for cumulative mouse-days at risk. The calculated RBE values for tritium beta rays compared to X rays ranged from 1.0 +/- 0.5 to 1.3 +/- 0.3. A best estimate of the RBE for this experiment was about 1.2 +/- 0.3. A wR value of 1 would thus appear to be more appropriate than a wR of 2 for tritium beta rays. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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