Intra-arterial reserpine for Raynaud's syndrome. Systemic reactions without therapeutic benefit

Autor:	R S, Surwit, R S, Gilgor, M, Duvic, L M, Allen, J A, Neal
Rok vydání:	1983
Předmět:	Adult Male Reserpine Brachial Artery Raynaud Disease Stroke Volume Middle Aged Double-Blind Method Injections Intra-Arterial Heart Rate Humans Female Cardiac Output Skin Temperature
Zdroj:	Archives of dermatology. 119(9)
ISSN:	0003-987X
Popis:	Twenty-four patients classified as having Raynaud's disease or Raynaud's phenomenon were given bilateral brachial artery injections of reserpine or saline in a double-blind fashion. In the six weeks following injection, there was no indication that reserpine produced clinical improvement or changed vasomotor reactivity in the treated patients. However, intra-arterial reserpine did produce systemic cardiovascular effects lasting up to six weeks. It is concluded that intra-arterial reserpine as used in this study is an ineffective treatment for Raynaud's disease or Raynaud's phenomenon and may have significant adverse effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::886beca3b76d16847fc404ab4688e170 https://pubmed.ncbi.nlm.nih.gov/6614959 Zobrazit plný text záznamu