| Autor: |
Udvardy, Miklos, Vladimir, Strugov, Catharina, Lewerin, Sebastian, Grosicki, Grzegorz, Mazur, Michael, Steurer, Marco, Montillo, Irina, Kryachok, Jan M, Middeke, Grygoriy, Rekhtman, Tommaso, Stefanelli, Ghislaine, Vincent, Sameera, Govindaraju, Anders, Österborg |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
British journal of haematologyReferences. 189(4) |
| ISSN: |
1365-2141 |
| Popis: |
In 2014, an interim analysis of a phase 3 study was performed to evaluate the effectiveness of ofatumumab in patients with bulky fludarabine-refractory chronic lymphocytic leukaemia (BFR CLL) as compared to physician's choice. The five-year follow-up of this phase 3 trial showed that ofatumumab therapy resulted in a numerically but not significantly longer overall survival. As only few patients had the chance to receive a kinase inhibitor later, the study displays the survival of BFR CLL patients in the period prior to receiving small-molecule inhibitors. Ofatumumab is a well-tolerable treatment option in multiresistant advanced CLL. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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