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As an unpleasant subjective feeling and emotional experience, pain has a negative impact on the physical and mental health of patients. In the early years, the research concerning pain mostly focused on the sensory-discriminative component. With the development of modern medicine, people found that the generation of affective-emotional component of pain has its unique physiological mechanism, and thus carried out a lot of in-depth research. The anterior cingulate cortex (ACC) is the main brain area activated by affective pain, and the regulation of acupuncture on pain aversion is mainly related to it. The mechanism includes various signal pathways, such as extracellular regulated protein kinases-mitogen activated protein kinase-cAMP-response element binding protein pathway, adenylate cyclase 1 protein kinase Mζ- glutamate receptor 1 pathway, contains many biomolecules, such as opioid receptors, neuropeptide S and its receptor, and refers to microglia at the cellular level. This article reviewed the neural mechanism of ACC involved in affective pain and the role of acupuncture played in this process.疼痛作为一种不愉快的主观感觉和情感体验给患者身心健康造成负面影响。早年对疼痛的研究多集中于感觉层面，随着现代医学的发展，人们发现痛厌恶情绪的产生有其独特的生理机制，并对此进行了深入研究。边缘系统中前扣带回(ACC)是痛厌恶情绪激活的主要脑区，而针刺对痛厌恶情绪的调节涉及ACC脑区各类信号通路，如细胞外调节蛋白激酶-丝裂原活化蛋白激酶-环磷腺苷效应元件结合蛋白通路、腺苷酸环化酶-蛋白激酶Mζ-谷氨酸受体1通路；包含多种生物分子，如阿片肽受体、神经肽S及其受体等；并在细胞层面通过ACC内小胶质细胞参与针刺的调控作用。本文就ACC参与痛厌恶情绪的神经机制及其在介导针刺缓解痛厌恶情绪中的研究进展进行综述。. |
