| Autor: |
Sineewanlaya, Wichit, Akanitt, Jittmittraphap, Kazuya I P J, Hidari, Butsaya, Thaisomboonsuk, Songsak, Petmitr, Sukathida, Ubol, Chie, Aoki, Saki, Itonori, Koichi, Morita, Takashi, Suzuki, Yasuo, Suzuki, Wipawee, Jampangern |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Microbiology and immunology. 55(2) |
| ISSN: |
1348-0421 |
| Popis: |
Dengue viruses infect cells by attaching to a surface receptor which remains unknown. The putative receptor molecules of dengue virus type 2 on the surface of mosquito (AP-61) and mammalian (LLC-MK2) cell lines were investigated. The immunochemical detection and structural analysis of carbohydrates demonstrated that the neutral glycosphingolipids, L-3 (GlcNAcβ1-3Manβ1-4Glcβ1-1'Cer) in AP-61 cells, and nLc(4) Cer (Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ1-1'Cer) in LLC-MK2 cells were recognized by the virus. These findings strongly suggest that neutral glycosphingolipids share the key determinant for virus binding and that the β-GlcNAc residue may play an important role in dengue virus binding to the host cell surface. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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