| Autor: |
T E, Starzl, G B, Klintmalm, R, Weil, K A, Porter, S, Iwatsuki, G P, Schroter, C, Fernandez-Bueno, N, MacHugh |
| Rok vydání: |
1981 |
| Předmět: |
|
| Zdroj: |
Surgery, gynecologyobstetrics. 153(4) |
| ISSN: |
0039-6087 |
| Popis: |
From nine to 18 months ago, 66 patients were given 67 randomly matched cadaveric kidneys with cyclosporin A and steroid therapy. Nine of the recipients were undergoing retransplantation. The over-all kidney survival rate to date has been 77.6 per cent, and 78.8 per cent of the recipients are dialysis-free. The patient mortality in this learning phase was 13.3 per cent. Nephrotoxicity, hepatotoxicity and other side-effects of cyclosporin A could usually be dealt with by dosage adjustments, making feasible the chronic use of this agent. One B-cell immunoblastic sarcoma was encountered which was monoclonal. It was not responsible for death. Another patient had a perforation of the intestine from a lympho-proliferative reaction in which the B cells were polyclonal. After jejunal resection a year ago, there were no further complications. This lesion was not classified as a lymphoma. Both lympho-proliferative lesions were associated with a rise in antibody to viral capsid antigen of Epstein-Barr virus. Results of this study have verified the effectiveness and relative safety of cyclosporin A with steroids for immunosuppression in human recipients of cadaveric kidneys. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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