| Autor: |
Cilmery Suemi, Kurokawa, Miriam, Hashimoto, Ligia Maria Suppo, de Souza Rugolo, Maria Regina, Bentlin, Marjorie de Assis, Golin, José Carlos, Peraçoli, Marcia Guimarães, da Silva, José Eduardo, Corrente, Saskia Maria Wiegerinck, Fekete |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
The Turkish journal of pediatrics. 55(6) |
| ISSN: |
2791-6421 |
| Popis: |
This study aimed to evaluate the levels of pro- and anti-inflammatory cytokines in umbilical cord blood of preterm neonates who developed focal early-onset infection (EOI) after preterm premature rupture of membranes (PPROM). This is a prospective study conducted on 46 preterm infants from mothers with PPROM. The cytokines were measure by flow cytometry. Newborns were classified into two groups as focal EOI (n=19) and non-infected (n=27). Interleukin (IL)-6 and IL-8 levels were higher, whereas IL-10 and IL-12 p70 levels were lower in the EOI when compared to the non-infected group. The best combination of cytokines was IL-6+IL-8, with a diagnostic accuracy of 0.97. Focal EOI after PPROM is associated with increased levels of IL-6 and IL-8 and diminished IL-10 and IL-12 in the cord blood of preterm infants. Combined assessment of IL-6 and IL-8 in cord blood may provide an additional tool for identifying preterm infants who develop EOI after PPROM. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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