Amplified biochemical activation of endothelial function in hypertension associated with moderate to severe renal failure
| Autor: | Santina, Cottone, Giuseppe, Mulè, Felicita, Amato, Raffaella, Riccobene, Anna, Vadalà, Maria C, Lorito, Francesco, Raspanti, Giovanni, Cerasola |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Endothelin-1 Angiotensin II Vascular Cell Adhesion Molecule-1 Enzyme-Linked Immunosorbent Assay Middle Aged Intercellular Adhesion Molecule-1 Nitric Oxide Prognosis Risk Assessment Sensitivity and Specificity Severity of Illness Index Up-Regulation Cohort Studies Reference Values Transforming Growth Factor beta Case-Control Studies Hypertension von Willebrand Factor Humans Endothelium Vascular Renal Insufficiency E-Selectin Probability |
| Zdroj: | Journal of nephrology. 15(6) |
| ISSN: | 1121-8428 |
| Popis: | Arterial hypertension and endothelial dysfunction have a role in the development of athero-sclerosis. This study assessed autocrine-paracrine endothelial function in patients with hypertension associated with renal failure.Angiotensin II (Ang II), endothelin-1 ( ET-1), basic fibroblast growth factor (bFGF), transforming growth factor-beta (TGF-beta), soluble forms of adhesion molecules (ICAM-1, VCAM-1), E-selectin, von Willebrand factor (vWf) and nitric oxide (NO) were measured in 26 patients with hypertension and chronic renal failure (CRF), in 19 essential hypertensives (EH) and in 28 normotensive healthy subjects.Plasma concentrations of Ang-II, ET-1, ICAM-1, VCAM-1, E-selectin, bFGF and TGF-beta all were significantly higher in patients than in healthy subjects and EH. Furthermore, in CRF, serum creatinine correlated negatively with NO plasma levels (r = - 0.51; p0.0) and this relationship held true after adjusting the data for potential confounders. Plasma NO was inversely related with ET-1 and bFGF (P0.01).Hypertension in CRF is characterized by biochemical evidence of marked endothelial dysfunction, apparently more pronounced than in patients with EH. Amplified endothelial activation in CRF probably contributes to the high rate of atherosclerotic complications in CRF. |
| Databáze: | OpenAIRE |
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