Constituents of
| Autor: | Htoo Tint, San, Tanawat, Chaowasku, Wanwimon, Mekboonsonglarp, Ratchanee, Rodsiri, Boonchoo, Sritularak, Hathairat, Buraphaka, Waraporn, Putalun, Kittisak, Likhitwitayawuid |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Neurons
Magnetic Resonance Spectroscopy Dose-Response Relationship Drug Molecular Structure diabetes Cell Survival Plant Extracts Phytochemicals Annonaceae Parkinsonism Article Rats glucose uptake Structure-Activity Relationship Huberantha jenkinsii Glucose Neuroprotective Agents Animals α-glucosidase Biomarkers |
| Zdroj: | Molecules |
| ISSN: | 1420-3049 |
| Popis: | The phytochemical investigation of Huberantha jenkinsii resulted in the isolation of two new and five known compounds. The new compounds were characterized as undescribed 8-oxoprotoberberine alkaloids and named huberanthines A and B, whereas the known compounds were identified as allantoin, oxylopinine, N-trans-feruloyl tyramine, N-trans-p-coumaroyl tyramine, and mangiferin. The structure determination was accomplished by spectroscopic methods. To evaluate therapeutic potential in diabetes and Parkinson’s disease, the isolates were subjected to assays for their α-glucosidase inhibitory activity, cellular glucose uptake stimulatory activity, and protective activity against neurotoxicity induced by 6-hydroxydopamine (6-OHDA). The results suggested that mangiferin was the most promising lead compound, demonstrating significant activity in all the test systems. |
| Databáze: | OpenAIRE |
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