Analysis of Unani coded formulation on the hormonal parameters of patients with polycystic ovarian syndrome
| Autor: | Leena, Hameed, Ahsana Dar, Farooq, Tasneem, Qureshi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Cinnamomum zeylanicum Adolescent Anti-Inflammatory Agents Luteinizing Hormone Antioxidants Metformin Prolactin Rats Vitex Mice Young Adult Medicine Unani Flax Sex Hormone-Binding Globulin Glycyrrhiza Animals Humans Hypoglycemic Agents Insulin Female Testosterone Plant Preparations Follicle Stimulating Hormone Polycystic Ovary Syndrome |
| Zdroj: | Pakistan journal of pharmaceutical sciences. 34(3) |
| ISSN: | 1011-601X |
| Popis: | The effect of Unani coded polyherbal formulations (Picolin) containing: 1) Cinnamomum verum (Bark), 2) Glycyrrhiza glabra (Root), 3) Linum usitatissimum (Seed) and 4) Vitex agnus castus (Seed) on the hormonal levels of polycystic ovarian syndrome (PCOS) patients (n=73) was determined. A randomized controlled multi-center trial was conducted on three groups that received either: 1) Capsule Picolin (n=25, 500 mg, two capsules thrice a day) and 2) Hydroalcoholic extract, tablet Picolin-E (n=23, 250 mg thrice a day) or 3) Metformin (n=25, 500 mg, twice a day) that continued for 12 weeks. The effect of capsule Picolin before and after treatment on serum insulin (14.8±1.8 vs 10.7±1.7μIU/mL) and prolactin (17.7±0.9 vs 8.5±1.1ng/mL) levels were significant. Likewise, the tablet Picolin-E also demonstrated significant effect on serum insulin (16.7±1.7 vs 9.3±0.1μIU/mL) and prolactin (18.5±1 vs 10±1.5ng/mL) levels. On the contrary in metformin treated group these parameters, serum insulin (17.4±1.6 vs 16.4±1.4μIU/mL) and prolactin (21.7±2.8 vs 21±2.8ng/mL) were non-significant. The improvement in the menstrual flow in the PCOS patients after treatment with either capsule Picolin, tablet Picolin-E or metformin were improved by 84%, 61% and 54%, respectively. Unani formulation were comparatively more effective than metformin. The treatment effectiveness was capsule Picolintablet Picolin-Emetformin. |
| Databáze: | OpenAIRE |
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