| Autor: |
A J, Venkatakrishnan, Praveen, Anand, Patrick J, Lenehan, Pritha, Ghosh, Rohit, Suratekar, Eli, Silvert, Colin, Pawlowski, Abhishek, Siroha, Dibyendu Roy, Chowdhury, John C, O'Horo, Joseph D, Yao, Bobbi S, Pritt, Andrew P, Norgan, Ryan T, Hurt, Andrew D, Badley, John, Halamka, Venky, Soundararajan |
| Rok vydání: |
2021 |
| Zdroj: |
Scientific reports. 13(1) |
| ISSN: |
2045-2322 |
| Popis: |
The emergence of highly transmissible SARS-CoV-2 variants and vaccine breakthrough infections globally mandated the characterization of the immuno-evasive features of SARS-CoV-2. Here, we systematically analyzed 2.13 million SARS-CoV-2 genomes from 188 countries/territories (up to June 2021) and performed whole-genome viral sequencing from 102 COVID-19 patients, including 43 vaccine breakthrough infections. We identified 92 Spike protein mutations that increased in prevalence during at least one surge in SARS-CoV-2 test positivity in any country over a 3-month window. Deletions in the Spike protein N-terminal domain were highly enriched for these 'surge-associated mutations' (Odds Ratio = 14.19, 95% CI 6.15-32.75, p value = 3.41 × 10 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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