| Autor: |
G P, Uko, M, Griffiths, R L, Dawkins, T, Cobain, I, Mohammed, C, Hedo, G, Okafor, A B, Umotong |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
African journal of medicine and medical sciences. 23(4) |
| ISSN: |
0309-3913 |
| Popis: |
Concentrations of immunoglobulins (IgA, IgG and IgM) were measured in Nigerians with (HIV) infection. Considerable elevations up to two-fold the reference values were observed for IgG and IgM in the patient group as a whole but elevations in IgA concentration were least marked albeit significantly different from the healthy subjects. Elevation of a particular isotype was not always concomitant with elevation of the other major classes in the same patient. Overall, these elevations were observed in both symptomatic and asymptomatic infected subjects. Further analysis of IgG hyperglobulinemia showed that increases in this major class may be due to increased IgG2 subclass concentrations. It is suggested that elevation of IgG2 subclass in Nigerians with HIV infection and not IgG1 or IgG3 may be due to genetic and environmental factors rather than variation in the strain of the virus.The major and subclass concentrations of immunoglobulins were examined in 27 Nigerians with HIV infection. 12 had definite HIV-1 infection, 2 had both HIV-1 and HIV-2, and the remaining 15 were included because of the reactivity of their sera. The reference group was drawn from four major Nigerian population groups that were part of a group of 238 healthy Nigerians. Individual increases in IgM and IgG concentrations in the patient group varied and was sometimes up to 7-fold above the mean of those in the control group. Overall, the increases were about twice the mean concentrations found in the reference group. The IgM concentration range was 0.6-9.7 g/l in the HIV group (n = 27) vs. 0.4-4.6 in the reference group (n = 157, p 0.02). The IgG concentration range was 10-70 g/l in the HIV group (n = 27) vs. 10-30 g/l in the reference group (n = 160, p .001). The highest IgG concentrations in cases were found in symptomatic patients, but this relationship was not observed for IgM and IgA. The scattergram of IgA concentrations was the least elevated. The increase was significant when those with HIV-1 infection alone were compared with the healthy subjects (p .05). IgG2 subclass concentrations were determined only in patients of Kanuri and Hausa populations. In comparison to their healthy counterparts, IgG2 concentrations were significantly higher in the patient group (p .001). Other IgG subclasses showed a bimodal distribution in both groups. There was no significant difference in distribution of IgG1, IgG3, and IgG4 concentrations between the reference and the HIV groups. In several ethnic groups polyclonal hypergammaglobulinemia has been reported to be a frequent feature of HIV infection with markedly increased IgA concentrations. The differences observed here do not reflect a variation in the strain of the virus in the Nigerian populations, but may be related to racial and environmental factors. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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