| Autor: |
Almudena, Val-Blasco, Patricia, Prieto, Rafael Iñigo, Jaén, Marta, Gil-Fernández, Marta, Pajares, Nieves, Domenech, Verónica, Terrón, María, Tamayo, Inmaculada, Jorge, Jesús, Vázquez, Andrea, Bueno-Sen, María Teresa, Vallejo-Cremades, Jorge, Pombo-Otero, Sergio, Sanchez-García, Gema, Ruiz-Hurtado, Ana María, Gómez, Carlos, Zaragoza, María Generosa, Crespo-Leiro, Eduardo, López-Collazo, Antonio, Cuadrado, Carmen, Delgado, Lisardo, Boscá, María, Fernández-Velasco |
| Rok vydání: |
2021 |
| Zdroj: |
JACC. Basic to translational science. 7(6) |
| ISSN: |
2452-302X |
| Popis: |
Specialized proresolving mediators and, in particular, 5(S), (6)R, 7-trihydroxyheptanoic acid methyl ester (BML-111) emerge as new therapeutic tools to prevent cardiac dysfunction and deleterious cardiac damage associated with myocarditis progression. The cardioprotective role of BML-111 is mainly caused by the prevention of increased oxidative stress and nuclear factor erythroid-derived 2-like 2 (NRF2) down-regulation induced by myocarditis. At the molecular level, BML-111 activates NRF2 signaling, which prevents sarcoplasmic reticulum-adenosine triphosphatase 2A down-regulation and Ca |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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