| Autor: |
X, Xu, M J, Stower, I N, Reid, R C, Garner, P A, Burns |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 6(8) |
| ISSN: |
1055-9965 |
| Popis: |
Twenty-eight transitional cell carcinomas of the bladder, grade 2 or 3, were analyzed for the presence of p53 mutations. Thirteen tumors were found to contain 14 mutations. These were all base substitution mutations, of which nine were GC--AT transitions (three at CpG sites). The remaining five mutations were transversions (three GC--CG, one GC--TA, and one AT--TA). Four of the mutations were found at codon 280. A comparison with other studies of bladder tumors reveals that a region encompassing codons 280 and 285 represents a hot spot for p53 mutation in bladder cancer. The 280/285 hot spot lies within two purine-rich sequences that may provide some clues to the identity of potential bladder carcinogens. A comparison of mutations from bladder tumors of smokers and nonsmokers reveals no significant differences. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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